Tris HCl - GMP Buffer
BIO PHARMA GRADE | TH4220 | CAS# 1185-53-1
INTENDED FOR USE IN PHARMACEUTICAL GMP PROCESSES
BIO PHARMA GRADE / TH4220
CAS #: 1185-53-1
Molecular Formula:
C4H11NO3 • HCI
Solubility in Water (g/L): 1,010
F.W.: 157.60 g/mol
pH @ 20°C: 7.0 - 9.0
pKa @ 20˚C: 8.2
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Tris Hydrochloride is a stabilizing buffer in biological applications such as electrochromatography, UV analysis and HPLC. It is used to adjust and stabilize the pH ranges for gels used in electrophoresis applications. Tris Hydrochloride is extensively used as a biological buffer or a component of buffer solutions.
These are general specifications. BioSpectra will customize our products to meet your quality based requirements.
| ANALYSIS | SPECIFICATIONS | ||
|---|---|---|---|
|
0.06 a.u. max. | ||
| Appearance and Color | White / Crystals | ||
| Assay, Dried | 99.5% min. | ||
|
None Detected None Detected None Detected |
||
| Heavy Metals | 2 ppm max. | ||
| Identification (IR) | Passes Test | ||
| Insoluble Matter | 0.001% max. | ||
| Loss on Drying at 105oC | 0.5% max. | ||
| Melting Range |
150 – 153°C |
||
| pH (0.5M) |
4.0-5.0 |
||
| pKa |
8.0-8.4 |
||
| Residue on Ignition | 0.1% max. | ||
| Solubility (1M) | Passes Test | ||
|
5 ppm max. 5 ppm max. 5 ppm max. 5 ppm max. 5 ppm max. 5 ppm max. |
| Key Compliance Attributes of BioSpectra Grades |
Bio Pharma Grade IPEC GMP Compliant Manufactured |
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|---|---|---|---|
|
Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Available | ||
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Available | ||
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Available | ||
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Available | ||
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Available | ||
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Available |
TRIS Hydrochloride General Product Description:
- BioSpectra manufactures Tris Hydrochloride TH4220 in its Stroudsburg, PA facility.
- Tris Hydrochloride is a White Crystalline product.
- Molecular Formula: C4H11NO3 • HCI
- Molecular Weight: 157.60 g/mol.
- CAS Number: 1185-53-1.
- There are no known major food allergens (as defined by FDA and WHO) in the manufacture of this product.
- BioSpectra certifies that all Tris Hydrochloride TH4220 manufactured at BioSpectra and its raw materials are not derived from or come in contact with animal parts, products, and/or byproducts.
- Tris Hydrochloride manufactured at BioSpectra and any raw materials used in the manufacture of Tris Hydrochloride at BioSpectra are not subject to genetic modification.
- Synonyms: Tris Hydrochloride, 2-Amino-2-(Hydroxymethyl)-1,3-Propanediol Hydrochloride; Tris (Hydroxymethyl) Aminomethane Hydrochloride.
TRIS Hydrochloride GMP Compliance:
Bio Pharma Grade Tris Hydrochloride TH4220 is manufactured in accordance with cGMP guidelines and is suitable to be used only as the following: IPEC Compliant GMP Manufactured Chemical, for use in further Manufacturing or as a Reagent for Laboratory and Research. This Grade of Tris Hydrochloride is not suitable to be used as an Active Pharmaceutical Ingredient, Drug, Drug Product or household item..
Expiration/Retest Date:
The recommended retest period for Tromethamine Hydrochloride is two years from the date of manufacture..
Storage and Shipping Conditions:
Ship and Store in ambient temperature.
Package Sizes:
TRIS HCl is available in 10kg, 25kg and 50kg pails.