Product Category

Ultra Diagnostic / Reagent Grade


Product Code: GTHI-5221 | Previously: GT5221

Intended For Use In Commercial Manufacturing, Diagnostic And Laboratory Applications

Guanidine Thiocyanate is a chaotropic agent. As one of the strongest protein denaturants, it inactivates nucleases more than twice as fast as Guanidine Hydrochloride. Guanidine Thiocyanate is preferred for the purification of RNA because it dissociates the RNA into its nucleic acids and protein forms. Higher molarity solutions of Guanidine Thiocyanate irreversibly inactivate RNase. Guanidine Thiocyanate causes proteins to dissolve readily, thus disintegrating cellular structures.

Product Specifications

Appearance and Color  
White / Crystals
Assay, Dried Basis  
≥ 99.0%



None Detected
None Detected
Heavy Metals (as Lead) ≤ 5ppm
Identification (IR)  
Conforms to Structure
Solubility (Colour)  
Solubility (Turbidity) 100mg/mL H2O  
Trace Metals

Barium (Ba)
Iron (Fe)
Potassium (K)
Sodium (Na)


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COAs and Tech Docs



CAS #: 593-84-0

Formula: C2H6N4S

Sol. In H2O (g/L): 1,600

F.W.: 118.16 g/mol

pH @ 20°C: 5.0 - 7.0

General Product Description:

  • Guanidine Thiocyanate is a White/Colorless Crystalline or Powder product.
  • Molecular Formula: C2H6N4S
  • Molecular Weight: 118.16 g/mol.
  • CAS Number: 593-84-0.
  • Synonyms: Guanidine Isothiocyanate.


Material represented by this grade is suitable to be used only as the following: Quality System Manufactured Process Chemical for use in further manufacturing or as a reagent chemical for commercial manufacturing, diagnostic and laboratory research. The material represented by this grade is not suitable to be used as an Excipient, Active Pharmaceutical Ingredient, Drug, Drug Product or household item.

Retest Date:

Two years from date of manufacture, testing and packaging.

Storage and Shipping Conditions:

Ship and Store in ambient temperature.

GHS Classification:


Signal Word: Danger

Hazard Statements:
    H302 - Harmful if swallowed
    H312 - Harmful in contact with skin
    H314 - Causes severe skin burns and eye damage
    H332 - Harmful if inhaled
    H412 - Harmful to aquatic life with long lasting effects

Package Sizes:

10kg, 25kg and 50kg pails.

Additional Packaging Information