MES, Monohydrate - GMP Buffer
BIO PHARMA GRADE | ME4220 | CAS# 145224-94-8
INTENDED FOR USE IN PHARMACEUTICAL GMP PROCESSES
BIO PHARMA GRADE / ME4220
CAS #: 145224-94-8
Molecular Formula:
C6H13NO4S·H2O
Solubility in Water (g/L): 310
F.W.: 213.25 g/mol
pH @ 20°C: 2.5 - 4.5
Useful pH: 5.5 - 6.7
pKa @ 20˚C: 6.1
MES Monohydrate is a zwitterionic buffer that is not absorbed through cell membranes and is virtually transparent in UV light. MES is a buffering agent used in many biological and biochemical applications. It is also used as a running buffer for denaturing gel electrophoresis.
The characteristics of low UV absorptivity, minimal reactivity, stable pH and solubility in water allow MES Monohydrate to be used as a Good’s buffer.
These are general specifications. BioSpectra will customize our products to meet your quality based requirements.
- Spec Sheet
- Product Inquiry
- Compliance
- C of As
- SDS
- Elemental Impurities
- Regulatory Packet
- Process Flow Diagram
- GMP Statement
- BSE/TSE
- Allergen
- GMO Statement
- Melamine
- Residual Solvents
- REACH
- Supply Chain
- TUPP
- Catalyst
| ANALYSIS | SPECIFICATIONS | |||||
|---|---|---|---|---|---|---|
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White / Crystals | |||||
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99.0% min. | |||||
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0.005% max. | |||||
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Colorless | |||||
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None Detected None Detected None Detected |
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2 ppm max. | |||||
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Passes Test | |||||
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7 - 10% | |||||
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3.0 – 3.5 | |||||
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2.5 – 4.5 | |||||
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5.9 – 6.3 |
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0.05% max. | |||||
|
Passes Test | |||||
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0.005% max. | |||||
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5 ppm max. 5 ppm max. 5 ppm max. 5 ppm max. |
| Key Compliance Attributes of BioSpectra Grades | Bio Pharma Grade IPEC GMP Compliant Manufactured | ||
|---|---|---|---|
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Available | ||
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Available | ||
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Available | ||
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Available | ||
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Available | ||
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Available |
General Product Description:
- The manufacturing of Bio Pharma Grade MES, Monohydrate ME4220 is performed at BioSpectra’s Bangor, PA facility utilizing multiuse equipment. Equipment used in the manufacturing of Bio Pharma Grade MES, Monohydrate is cleaned in accordance with BioSpectra’s Cleaning Validation Plan.
- MES is a White Crystalline product.
- Molecular Formula: C6H13NO4S·H2O
- Molecular Weight: 213.25 g/mol.
- CAS Number: 145224-94-8.
- There are no known major food allergens (as defined by FDA and WHO) in the manufacture of this product.
- BioSpectra certifies that all MES, Monohydrate ME4220 manufactured at BioSpectra and its raw materials are not derived from or come in contact with animal parts, products, and/or byproducts.
- MES, Monohydrate manufactured at BioSpectra and any raw materials used in the manufacture of MES, Monohydrate at BioSpectra are not subject to genetic modification.
- Synonyms: 2-(N-Morpholino)ethanesulfonic acid, 4-Morpholineethanesulfonic acid monohydrate.
GMP Compliance:
Bio Pharma Grade MES, Monohydrate ME4220 is manufactured in
accordance with cGMP guidelines and is suitable to be used only
as the following: IPEC Compliant cGMP Manufactured Chemical,
for use in further Manufacturing or as a Reagent for Laboratory
and Research. This Grade of MES, Monohydrate is not suitable
to be used as an Active Pharmaceutical Ingredient, Drug, Drug
Product or household item.
Expiration/Retest Date:
The recommended retest period for MES, Monohydrate is two
years from the date of manufacture.
Storage and Shipping Conditions:
Ship and Store in ambient temperature.
Package Sizes:
10kg, 25kg and 50kg pails.