Guanidine Thiocyanate - GMP Denaturant
BIO PHARMA GRADE | GT4220 | CAS#: 593-84-0
INTENDED FOR USE IN PHARMACEUTICAL GMP PROCESS
BIO PHARMA GRADE / GT4220
CAS #: 593-84-0
Molecular Formula:
C2H6N4S
Solubility in Water (g/L): 1,600
F.W.: 118.16 g/mol
pH @ 20°C: 5.0 - 7.0
Guanidine Thiocyanate is a chaotropic agent. As one of the strongest protein denaturants, it inactivates nucleases more than twice as fast as Guanidine Hydrochloride. Guanidine Thiocyanate is preferred for the purification of RNA because it dissociates the RNA into its nucleic acids and protein forms. Higher molarity solutions of Guanidine Thiocyanate irreversibly inactivate RNase. Guanidine Thiocyanate causes proteins to dissolve readily, thus disintegrating cellular structures.
These are general specifications. BioSpectra will customize our products to meet your quality based requirements.
- Spec Sheet
- Quick Inquiry
- Compliance
- C of As
- SDS
| ANALYSIS | SPECIFICATIONS | |||||||||
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White / Crystals | |||||||||
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99.5% minimum. | |||||||||
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None Detected None Detected None Detected |
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Passes Test | |||||||||
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0.5% max. | |||||||||
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115-121ºC |
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5.0-7.0 | |||||||||
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Clear | |||||||||
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5 ppm max. 5 ppm max. 5 ppm max. 5 ppm max. |
| Key Compliance Attributes of BioSpectra Grades | Bio Pharma Grade IPEC GMP Compliant Manufactured | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Available | ||
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Available | ||
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Available | ||
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Available | ||
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Available | ||
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Available |
General Product Description:
• BioSpectra manufactures Bio Pharma Grade Guanidine Thiocyanate GT4220 in its Bangor, PA facility. Guanidine Thiocyanate is packaged, stored, tested, and released at BioSpectra’s Bangor, PA facility.
• Guanidine Thiocyanate is a White Crystalline product.
• Molecular Formula: C2H6N4S
• Molecular Weight: 118.16 g/mol.
• CAS Number: 593-84-0.
• There are no known major food allergens (as defined by FDA and WHO) in the manufacture of this product.
• BioSpectra certifies that all Guanidine Thiocyanate GT4220 manufactured at BioSpectra and its raw materials are not derived from or come in contact with animal parts, products, and/or byproducts.
• Guanidine Thiocyanate manufactured at BioSpectra and any raw materials used in the manufacture of Guanidine Thiocyanate at BioSpectra are not subject to genetic modification.
• Synonyms: Guanidine Hydrothiocyanate, Guanidine Isothiocyanate, Guanidine Monothiocyanate.
GMP Compliance:
Bio Pharma Grade Guanidine Thiocyanate GT4220 is manufactured in accordance with cGMP guidelines and is suitable to be used only as the following: IPEC Compliant cGMP Manufactured Chemical for use in further manufacturing or as a reagent for laboratory and research. The material represented by this grade is not suitable to be used as an Active Pharmaceutical Ingredient, Drug, Drug Product or household item.
Expiration/Retest Date:
The recommended retest period for Guanidine Thiocyanate is two years from the date of manufacture.
Storage and Shipping Conditions:
Ship and Store in ambient temperature.
Package Sizes:
10kg, 25kg and 50kg pails.