Product Category

GMP Denaturant

GMP Manufactured Process Chemical

GUANIDINE THIOCYANATE
GMP Grade

Product Code: GTHI-4220 | Previously: GT4220

Intended Use Statement


Guanidine Thiocyanate is a chaotropic agent. As one of the strongest protein denaturants, it inactivates nucleases more than twice as fast as Guanidine Hydrochloride. Guanidine Thiocyanate is preferred for the purification of RNA because it dissociates the RNA into its nucleic acids and protein forms. Higher molarity solutions of Guanidine Thiocyanate irreversibly inactivate RNase. Guanidine Thiocyanate causes proteins to dissolve readily, thus disintegrating cellular structures.

Product Specifications

ANALYSIS SPECIFICATIONS
  280 nm
Absorbance 300 nm
  340 nm
0.300 a.u. maximum
0.050 a.u. maximum
0.030 a.u. maximum
Appearance and Color  
White / Crystals
Assay  
99.5% minimum.
Enzymes

DNase

Protease

RNase

None Detected
None Detected
None Detected
Identification (IR)  
Passes Test

Loss on Drying

 
0.5% max.
Melting Range  

115-121ºC

pH (5% solution)  
5.0-7.0
Solubility (35%)  
Clear
Trace Metals

Arsenic (As)

Copper (Cu)

Iron (Fe)

Lead (Pb)

5 ppm max.
5 ppm max.
5 ppm max.
5 ppm max.
Printable Version
Key Compliance Attributes of BioSpectra Grades Bio Pharma Grade IPEC GMP Compliant Manufactured
Suitable for Research and Diagnostic  
Yes-image
Each Batch 100% Analyzed  
Yes-image
Management of Change  
Yes-image
Validated Analytical Methods  
Yes-image
Compendial Testing  
Yes-image
Trace Metals Analyzed  
Yes-image
Stability Testing Program  
Yes-image
BioSpectra Supply Chain Audit Trail  
Yes-image
Product Origin Statement  
Yes-image
Customer Quality Audits  
Yes-image
Validated Manufacturing Process  
Yes-image
US Manufactured at BioSpectra  
Yes-image
IPEC cGMP Compliant Manufactured  
Yes-image
Customized Additional Specifications Yes-image
Multi-Compendial Testing  
Yes-image
Low Bioburden Low Endotoxin (LBLE)  
Yes-image
Enzyme Tested  
Yes-image
Suitable for use as Excipient  
Yes-image
Microbial / Endotoxin Tested  
Yes-image
Manufactured in FDA Registered Facility  
Yes-image
Customized Manufacturing Schedule  
Yes-image
Custom Regulatory Packet  
Yes-image
Accelerated Stability  
Yes-image
Video Conference access to BioSpectra Sites  
Yes-image
Complete access to Product Traceability  
Yes-image
Access to Supply Chain Information  
Yes-image

Yes-imageindicates an attribute or level of compliance which is granted or available based on the purchase of the product grade.
Bio Pharma Grade: Intended for use as IPEC cGMP Compliant Chemical
LBLE: LBLE applies when product specifications include requirements for Bioburden Testing (TAMC/TYMC and/or Endotoxin).
LBLE stands for Low Bioburden, Low Endotoxin non-sterile products suitable for further use in parenteral manufacturing and other sterile applications.

 

Product Inquiry

Please enter your first name

Please enter title

Please enter product of interest

Enter name of company

Please enter your last name

Please enter your valid email address

Enter position in company

Location of company
Please enter street address

Enter your company state

Invalid Input

Please enter city

Enter zip code

Enter Country

Enter country code

Enter phone number

Enter web address

Please select any option

If resale please fill out the following information
Enter end use customer's full name

Enter end use customer's address

Please select any option

Please select any one option

Please select any option

Invalid Input

Please select any one option

Invalid Input

Invalid Input

Please enter Estimated Release quantity in Liters or Kg

Please enter Regulatory Requirements

Please enter timeframe needed

Please enter Estimated annual demand in liters or kg

Please enter Logistics: Freight

Please enter specificatoin

Validate Recaptcha

General Product Description:

  • BioSpectra manufactures Bio Pharma Grade Guanidine Thiocyanate GTHI-4220 in its Bangor, PA facility. Guanidine Thiocyanate is packaged, stored, tested, and released at BioSpectra’s Bangor, PA facility.
  • Guanidine Thiocyanate is a White Crystalline product.
  • Molecular Formula: C2H6N4S
  • Molecular Weight: 118.16 g/mol.
  • CAS Number: 593-84-0.
  • There are no known major food allergens (as defined by FDA and WHO) in the manufacture of this product.
  • BioSpectra certifies that all Guanidine Thiocyanate GTHI-4220 manufactured at BioSpectra and its raw materials are not derived from or come in contact with animal parts, products, and/or byproducts.
  • Guanidine Thiocyanate manufactured at BioSpectra and any raw materials used in the manufacture of Guanidine Thiocyanate at BioSpectra are not subject to genetic modification.
  • Synonyms: Guanidine Hydrothiocyanate, Guanidine Isothiocyanate, Guanidine Monothiocyanate.

 



GMP Compliance:

Bio Pharma Grade Guanidine Thiocyanate GTHI-4220 is suitable for use as a process chemical. It is manufactured in accordance with the IPEC-PQG Joint Good Manufacturing Practice Guide. This grade of Guanidine Thiocyanate is not suitable to be used as an Active Pharmaceutical Ingredient, Drug, Drug Product or Household Item.

GHS Classification:

Pictograms 

Signal Word: Danger

Hazard Statements

H302 - Harmful if swallowed
H312 - Harmful in contact with skin
H314 - Causes severe skin burns and eye damage
H332 - Harmful if inhaled
H412 - Harmful to aquatic life with long lasting effects

Retest Date:

The recommended retest period for Guanidine Thiocyanate is two years from the date of manufacture.

Storage and Shipping Conditions:

Ship and Store in ambient temperature.

Package Sizes:

10kg, 25kg and 50kg pails.