Guanidine HCl 6M - GMP Denaturant
BIO PHARMA GRADE | GH4120 | CAS# 50-01-1
INTENDED FOR USE IN PHARMACEUTICAL GMP PROCESSES
Guanidine Hydrochloride 6M solution can be used to denature proteins which become randomly coiled with no residual structure. This concentration is also used to decrease enzyme activity.The denatured proteins can be modified or analyzed using mass spectrometry, electrophoresis and enzymatic digests. As a chaotropic agent, Guanidine Hydrochloride solution is also used to break the hydrogen bonds in the structure of proteins and increase the solubility of hydrophobic molecules.
These are general specifications. BioSpectra will customize our products to meet your quality based requirements.
BIO PHARMA GRADE / GH4120
CAS #: 50-01-1
Molecular Formula:
CH5N3 • HCl
Solubility in Water (g/L): 573
F.W.: 118.16 g/mol
pH @ 20°C: 4.5 - 6.0
pKa @ 20˚C: 13.6
- SDS
- Spec Sheet
- Compliance
- C of As
| ANALYSIS | SPECIFICATIONS | ||
|---|---|---|---|
|
Clear, Colorless Liquid | ||
|
< 10 ppm | ||
|
Passes Test | ||
|
≤ 3 ppm | ||
|
5.5-6.5 M |
| Key Compliance Attributes of BioSpectra Grades | Bio Pharma Grade IPEC GMP Compliant Manufactured | ||
|---|---|---|---|
|
Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Yes | ||
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Available | ||
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Available | ||
|
Available | ||
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Available | ||
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Available | ||
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Available |
| PDF's | |
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General Product Description:
- The manufacturing of Guanidine Hydrochloride GH4120 is performed at BioSpectra’s Stroudsburg, PA facility utilizing dedicated equipment. Equipment used in the manufacturing of GH4120 is cleaned in accordance with BioSpectra’s Cleaning Validation Plan
- Guanidine Hydrochloride 6M is a clear colorless solution.
- There are no known major food allergens (as defined by FDA and WHO) in the manufacture of this product.
- BioSpectra certifies that all Guanidine Hydrochloride 6M GH4120 manufactured at BioSpectra and its raw materials are not derived from or come in contact with animal parts, products, and/or byproducts.
- Guanidine Hydrochloride 6M manufactured at BioSpectra and any raw materials used in the manufacture of Guanidine Hydrochloride 6M at BioSpectra are not subject to genetic modification.
- Synonyms: Guanidine Monohydrochloride, Guanidinium Chloride, Guanidinium Hydrochloride.
- Manufactured with USP grade purified water.
GMP Compliance:
Bio Pharma Grade Guanidine Hydrochloride 6M GH4120
is manufactured in accordance with GMP guidelines
and is suitable to be used only as the following: IPEC
Compliant GMP Manufactured Chemical, for use in
further Manufacturing or as a Reagent for Laboratory
and Research. This Grade of Guanidine Hydrochloride 6M
is not suitable to be used as an Active Pharmaceutical
Ingredient, Drug, Drug Product or household item.
Expiration/Retest Date:
The recommended retest period for Guanidine
Hydrochloride 6M is two years from the date of manufacture.
Storage and Shipping Conditions:
Ship and Store in ambient temperature.
Package Sizes:
Available in 200L drums and totes.